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KMID : 0359920070260060767
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Korean Journal of Nephrology
2007 Volume.26 No. 6 p.767 ~ p.771
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A Case of Castleman’s Disease with Kidney Involvement
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Won Ji-Eon
Jeong Sun-Joo
Cho Jai-Hyun
Kim Je-Yeol
Kim Eun-Jung
Kim Hyung-Jik
Song Young-Rim
Nam Eun-Suk
Kim Seong-Gyun
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Abstract
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Castleman’s disease is a rare disorder of unknown etiology that results in the unregulated growth of lymphoid tissue. It can be classified as unicentric and multicentric based on clinical and radiological findings, and also as hyaline vascular and plasma cell type based on histopathology. Castleman’s disease may present as an asymptomatic involvement of one lymph node group or as a multicentric disease with systemic features. However, renal involvement is very rare.
Here we report a 50-year old male patient with histopathologically proven multicentric plasma cell type of Castleman’s disease who presented with weight loss, palpable cervical lymphadenopathy, azotemia and proteinuria. The finding of a percutaneous needle renal biopsy was compatible with plasma cell type of Castleman’s disease. After treated with systemic corticosteroid, azotemia and proteinuria disappeared.
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KEYWORD
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Castleman’s disease, Plasma cells, Kidney
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